“EXPERIMENTAL & CLINICAL MEDICINE”
2004 N1-2
MATERIALS OF THE IV TBILISI INTERNATIONAL CONFERENCE
(DECEMBER 19-20, 2003)
TRANSESOPHAGEAL ECHOCARDIOGRAPHY - EDDITIONAL DATA FOR PREDICTING LONG-TERM MAINTENANCE OF SINUS RHYTHM AFTER SUCCESSFUL CARDIOVERSION
M.Tsinamdzgvrishvili Institute of Cardiology, Tbilisi Heart and Vascular Clinic, Georgia
ABSTRACT. Long-term maintenance of sinus rhythm after successful cardioversion (CV) is one of the most difficult problems in the treatment of atrial fibrillation (AE).
There are several clinical and echocardiographic predictors of long-term maintenance of SR after CV: left atrial size <44 cm, shorter AF duration, preserved left ventricular (LV) function, absence of valve disease. In recent years several studies have suggested that long-term SR maintenance may be predicted by evaluating LAA velocities before CV.
86 patients with chronic atrial fibrillation were studied. Duration of AF was >48 hours and <1 year. Electrical cardioversion (external) was successful in 75 patients (87%). One year maintenance of SR was assessed. Transthoracic echocardiographic, transesophageal echocardiographic data were analyzed before, after 1 week and every 3 months during a year.
After one year follow-up, from 72 patients (3 patients were excluded from the study) SR was maintained in 41 ones: in 26 patients (67%) from 37 ones receiving antiarrhythmic drugs, and in 15 (43%) patients from 35, who were not receiving antiarrythmic drugs. Mean LAA peak emptying velocity was higher in patients, in whom SR remained (40-60 cm/s) after one year, irrespective the fact whether they had received antiarrythmic drugs or not. In patients with low LAA flow velocity (20-30cm/s), SR maintained only in few cases, though most of them had been receiving (taking) antiarrythmic treatment.
According to our results, mean LAA peak emptying velocity may be used as a predictor of long- term sinus rhythm maintenance in patients with atrial fibrillation.
G.ABULADZE, K.VAKHTANGADZE, B.TURKIA, D.KANTARIA, L.CHAVCHANIDZE, E.NIKUCHADZE, Sh.ESIASHVILI
THE MODERN ASPECTS OF TREATMENT AND PREVENTION OF ATRIAL FIBRILLATION
M. Tsinamdzgvrishvili Institute of Cardiology, Tbilisi, Georgia
ABSTRACT. The present article reflects up-to-date aspects of AF treatment and prevention according to the respective guidelines of the American and European Cardiological Societies. It involves new clinical classifications, new treatment and prevention strategies based on patient clinical status, as well as the applications of antyarrythmic drugs of different classes (with respect to their arrythmogenic effects) in patients with structural heart disease and in those with normal hearts.
M.AMIRANIDZE, M.SOSELIA, M.DGEBUADZE
COMPARATIVÅ ESTIMATION OF MORPHOLOGICAL CHANGES OF THE SPLEEN AND LIVER OF RATS AFTER THE WHOLE-BODY X-IRRADIATION AND SUBSEQUENT PARTIAL SPLENECTOMY
A.Natishvili Institute of Experimental Morphology of Georgian AS, Tbilisi
ABSTRACT. Light microscopy was used to study the spleen and liver of rats after the whole-body x-irradiation in two groups: 1. after subsequent partial resection of the spleen and 2. the whole-body x-irradiation of rats on the 2, 7 and 15 days of the experiment. During experiment, on the early time of the investigation in both groups were noticed discirculatory and dystrophic changes of the spleen and liver. After the whole-body x-irradiation and subsequent partial splenectomy, there were observed fewer necrobiotic changes of hepatocytes than after the whole-body x-irradiation only. We suggest that this may be even provoked by an operation on the spleen. We think that immune reaction to antigens coming from traumatized tissues of the spleen takes place. May be antitoxic immunity is one of the factors of radiotoxins blocking activity on the liver.
M. BOKHUA, E. DAUSHVILI, T. GRIGOLASHVILI, N. NADIRADZE
EFFECT OF ACE INHIBITOR AND BETA-BLOCKER ON HEMODYNAMIC PARAMETERS AND LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN PATIENTS WITH CONGESTIVE HEART FAILURE
Ltd Clinic “Grandi”, Department of Cardiology, Tbilisi, Georgia
ABSTRACT. The aim of the study was to establish a hemodynamic and functional effect of ACE inhibitor - Diroton and beta-blocker - Concor in patients with the congestive heart failure syndrome. Two-dimensional Doppler echocardiography and 24-hour Holter blood pressure monitoring were used in the examination of 48 patients (30 men and 18 women, age 64+7 years) with chronic heart failure NYHA (functional class II-III) and mild-to-moderate hypertension. Patients were divided into 2 groups: in the1st group - Diroton and diuretic were used, in the 2nd group - Diroton, diuretic and Concor. These results can serve as a basis for the use of ACE inhibitor and beta-blocker for treating left ventricular systolic dysfunction in patients with the congestive heart failure syndrome.
CANCER AS A HISTOGENETICALLY INDIVISIBLE SYSTEM
ABSTRACT. Based on the current morphological investigation, we established that carcinoma parenchymal cell produces and secretes various substances useful for tumor fibrous component. In the mammary glands and chorionic villi we described at first undifferentiated multipotential (cambia) cells, attached to the basement membrane. These cells are able to differentiate into various forms.
After malignization, these cells form tumor parenchyma surrounding fibrous structures and capillaries. The data confirm our hypothesis that cancer parenchyma and stroma are complete formation, where parenchyma and stroma are responsible for aggressive growth of the tumor.
PROGNOSTIC VALUE OF PERIFOCAL BRAIN TISSUE DAMAGE DURING DISLOCATION PROCESSES CONDITIONED BY TEMPORAL LOBE TUMORS
Neurosurgical Clinic of Tbilisi Hospital ¹1, Georgia
ABSTRACT. The question on the character of structural and functional changes in brain tissue locating near the center of tumor growth is the most essential.
300 patients with temporal lobe tumor and 85 observations of the section material used for the definition of structural changes in the stem part of the brain served as material for the research. Also were studied visual changes of the stem and medio-basal segments, and the changes around the tumor.
During dislocation, there was marked the asymmetry of the large hemispheres by the increase of a lesioned part, significant full-bloodedness of bran vessels, smoothening of crinkles and gyri in this region. The central line was displaced to the opposite side. Edema-dependent was the displacement of gyrus hippocampus herniation into the Bisha foramen.
More important in dislocation is primary intralobular localization of a pathological process in the limits of the temporal share. During medio-basal localization of tumors, they basically appear to be malignant, seldom accompanied (in contrast with the other parts of the temporal share) with epileptic seizures, whereas dislocation in them occurs much more frequently.
The analysis of the section material has shown that change-striking of the brain and perifocal tissue by a tumor is various and dependent on localization, histology, volume and rate of growth of a tumor.
During the increase of intracranial pressure in a phase of rough decompensation of the disease the epileptic seizures faded quickly (or disappeared in general) conceding place to stem symptoms. They are extremely rare in terminal and dislocation stage of the disease. The occurrence of tonic seizures in a clinic picture of disease indicates the presence of pressure of a tumor on the stem portion of the brain, or possible herniation of medio-basal segments of the temporal lobe in the hole of Bisha.
The safety of nervous cells applied to a tumor has huge meaning in the formation of dislocation.
We received a favorable outcome after the surgical treatment of intracerabral tumors as a result of the maximally radical removal of a tumor, especially in case of those tumors of the temporal share which are accompanied by epileptic seizures.
The purpose of operative intervention should be total removal of a tumor with surrounding brain structures up to the border with unchanged brain tissue.
THE INFLUENCE OF PLASMAPHERESIS ON INTOXICATION MARKERS IN PATIENTS
WITH G-6-PD ENZYME DEFICIENCY
Medical Center “SHAFA”, Baku, Azerbaijan
ABSTRACT. The purpose of this research was to investigate intoxication markers in the patients with G-6-PD deficiency, and to estimate also the efficiency of plasmapheresis for the correction of the revealed changes. The application of PA for G-6-PD deficiency patients has normalized the level of intoxication.
THE PREVALENCE OF HCV ANTIBODY IN THALASSEMIA MAJOR PATIENTS RECEIVING REGULAR HEMOTRANSFUSION
All-Russian Scientific Center of Surgery, Moscow, Russia
Medical Center “Shafa” Baku, Azerbaijan
ABSTRACT. Among the general group of Thalassemia Major patients (100 men) receiving regular hemotransfusion, 4 (4 %) patients had antibodies to hepatitis C virus. In the age group 16-20 years, HCV antibody was found in 6.7 %. Among the patients aged 11-15, the frequency of anti-HCV antibody was 3.3 %, and the least frequency of antibodies was found in patients younger than 11years - 2.5 %.
THE ACTION OF PLAFERON ON THE IMMUNE INDICATIONS IN PATIENTS WITH RHEUMATIC DISEASE
The Institute of Medical Biotecnology of the Academy of science of Georgia,
A.Natishvili Institute of Experimental Morphology Georgian AS, Tbilisi
ABSTRACT. There were studied the immune system condition in the patients with rheumatic heart disease and the influence of Plapheron-LB on them.
As the results Shaw, after the treatment all disturbed immunological indices (points) where normalized and positive dynamic was obvious.
THE INFLUENCE OF PLAFERON-LB ON THE NATRIURETIC SYSTEM IN PATIENTS WITH RHEUMATIC HEART DISEASE
The Institute of Medical Biotechnology of Georgian AS, Tbilisi
ABSTRACT. There were studied the natriuretic system condition in patients with rheumatic heart disease (among them were some cases complicated with chronic heart insufficiency) and the influence of Plapheron-LB on them.
As the results Shaw, the inhibition effect of Plapheron-LB on activity of Na, k-ATF-aza and the improvement of inotropic function of heart make possible to use Plapheron-LB in the complexive treatment of rheumatic heart disease and chronic heart insufficiency.
ANTIDROMIC IDENTIFICATION OF AMYGDALOID LATERAL NUCLEUS EFFERENT NEURONS
Iv.Beritashvili Institute of Physiology of Georgian AS, Tbilisi
ABSTRACT. Antidromically identified neurons were recorded from the lateral nucleus of amygdaloid complex in anesthetized cats during ventral amygdalofugal tract stimulation. The action potentials were considered antidromic because they showed short and stable latencies, followed by short trains of high frequency stimulation at 250 Hz and more and could be blocked by orthodromic collision. The latencies of antidromic spikes ranged from 0.8 to 3.0ms. That corresponded to conduction velocities between 1.3 – 2.8m/sec. The antidromic activation was always curtailed by an inhibition, which indicates the existence of the recurrent inhibition.
Z.M. TOPURIA, T.G.MOSIDZE
Department of Pathologic Anatomy and Legal Medicine of Tbilisi State Medical Academy, Georgia
ABSTRACT. Histological and ultrastructural peculiarities of the lung are discerned in the experiments with alcoholic intoxication in 120 albino rats.
A single moderate dose of ethanol provokes reactive disturbances in the microcirculatory network, but no morphological changes are found in the alveolar structure.
In chronic alcoholic intoxication with a withdrawal syndrome, type II alveolocytes and lung surfactant system are damaged.
I.I.TOPURIDZE1, M.G.GADABADZE2, D.T.KHACHIDZE3, I.T.CHUADZE2, R.T. SRESELI1
DIAGNOSIS OF VARIABLE BONE AND BONE MARROW LESIONS BY THE METHOD OF DIFFERENTIAL SCANNING MICROCALORIMETRY
1Chair of Hematology and Transfusiology of the Medical Academy
2Scientific-Research Institute of Hematology and Transfusiology
3Institute of Physics of AS, Tbilisi, Georgia
ABSTRACT. We have investigated patients with several malignant and non-malignant lesions of bone and bone marrow by the method of differential scanning microcalorimetry. In each disease were identified the characteristic variations of protein fusion, which give the valuable information for differential diagnosis.
The above-mentioned method, is characterized by several advantages in comparison with other molecular diagnostic methods, especially for bone tumors which are difficult to diagnose.
I.I.TOPURIDZE1, M.G.GADABADZE2, D.T.KHACHIDZE3, I.T.CHUADZE2, R.T.SRESELI1
PROTEIN FUSION VARIATIONS IN SERUM OF PATIENTS WITH ACUTE LEUKEMIA – THEIR IMPORTANCE IN DIAGNOSIS, PROGNOSTICATION, AND IN DETERMINING THE EFFECTIVENESS OF TREATMENT
1Chair of Hematology and Transfusiology of the Medical Academy
2Scientific-Research Institute of Hematology and Transfusiology
3Institute of Physics of AS, Tbilisi, Georgia
ABSTRACT. We evaluated the “extracellular markers”- protein fusions - in the serum of patients with acute leukemia by the method of differential scanning microcalorimetry.
There was determined the diagnostic and prognostic value of this fusion variations, by which were clarified the possibilities of treatment result improvement for patients with acute leukemia.
The above-mentioned method is characterized by several advantages in comparison with the other diagnostic methods using molecular-degree complexive examinations of the biological system.
M. IAKOBIDZE, M. CHKHATARASHVILI, T. AKOBIA, R.MAISURADZE
INTENSIVE THERAPY OF GASTROINTESTINAL HEMORRHAGE DEVELOPED DURING TRAUMATIC INJURIES
ABSTRACT. We have examined case histories of 32 patients with trauma disease. During reanimation measures they were registered to have gastro-duodenal hemorrhage. Patients with multiple and combined traumatic injuries complicated with II-III degree shock were treated at the Department of Critical Care.
Tissular hypoperfusion and hypotension resulting from shock favored the development of erosion and superficial (symptomatic) acute gastric ulcer. The cause of acute gastro-duodenal hemorrhage is the development of disseminated intravascular coagulation syndrome.
The principles of conservative treatment of occurring acute gastrointestinal hemorrhage are as follows: Complex anti-shock therapy and coagulopathy correction; Influencing the acid-base factor by blocking H2–histamine receptors, prescription of gastroprotectors; Strengthening and recovery of histic metabolism; Active use of protein-degrading (proteolytic) enzymes inhibitors; Prescription of a special diet and regimen.
N.IARAJULI, G.LOTUASHVILI, R.STEPANIAN
METALLOOSTEOSYNTHESIS OF OBLIQUE SPIRAL FRACTURE OF THE TIBIA WITH A CLOSED METHOD
J.S.C. “Travmatology”, Tbilisi, Georgia
ABSTRACT. 67 operations of oblique spiral fractures of the tibia have been performed in our hospital, using metalloostheosyntesis closed method.
The effectiveness is characterized as follows: 1. The method is simple, safe and accessible, and doesn’t need special equipment. 2. There is no necessity in long-term hospital treatment. 3. Postoperational complications are minimal. 4. The operation is performed without narcosis. 5. The treatment is economically effective. 6. Patients recover full activity and the capacity for work in 4-5 months.
K.KANDELAKI
NEW WAYS OF LOCAL DELIVERY OF MEDICINES WITH PROLONGED ACTION IN THE TREATMENT OF PERIODONTAL DISEASES
A.Natishvili Institute of Experimental Morphology of Georgian AS, Tbilisi
ABSTRACT. The clinical effect of the application of biodegradable films in the treatment of periodontal diseases has been estimated.
There were 17 patients with chronic periodontal disease under our observation. All the patients were divided into 2 groups.
The first group of patients (9 persons) was treated by biodegradable films, but the other group (8 persons) – by the traditional antiinflammatory methods of treatment.
It was detected that biodegradable films showed the most effective results in the treatment of periodontal diseases.
MAMEDOV R. A., JAFAROV C. M., GASIMOV E. M.
QUANTITATIVE CHARACTERISTIC AND FUNCTIONAL ACTIVITY OF NEUROENDOCRINE CELLS IN PROGNOSTICATION OF STOMACH AND DUODENAL ULCER COMPLICATIONS
General Surgery Department, AMU, Baku, Azerbaijan
ABSTRACT. The issues of morphofunctional condition and significance of the endocrine cells of gastric mucosa in prognostication of frequently occuring complications of ulcer disease are currently under discussion.
According to the references, there is still a high frequency of gastric ulcer disease complications even during the adequate systematic use of modern medicines. The latter doesn’t influence the frequency of ulcer disease complications, but only postpones them. The currently assigned place of changes in the endocrine cells of gastric mucosa at the origin of ulcer disease determines the growing interest in them for the prognosis of its complications.
Tbilisi Scientific and Practical Center of Clinical Pathology, Georgia
ABSTRACT. The purpose of this investigation was to study a morpho-functional state of the adenohypophysis and thyroid gland during postreanimation period. An apparent death was modelled in dogs by a free bloodletting from the femoral artery.
It is established that during postreanimation period, there are marked processes of functional activation (0,5-48 hour), depression (2-18 days) and secondary activation (18-30 days) in the morpho-functional state of the adenohypophysis and thyroid gland.
Our results show that animals needs necessary functional correction during the postreanimation period.
O. MIRIANASHVILI
SOME DATA ON ETHYOPATHOGENESIS OF INGUINAL HERNIA
Ltd “The Railway of Georgia”, the Urology Department of the Central Clinical Hospital, Tbilisi, Georgia
ABSTRACT. In addition to not-obliterated appendix-like fold of the peritoneum and known causes of congenital hernia, early delivery has a very important role because of incomplete obliteration of the appendix-like fold of the peritoneum in premature newborns.
Interesting results were obtained in 68 premature newborns - 35 female and 33 male. In 33 male newborns only 3 had the testicles descended into the scrotum and in the rest 30 male newborns the testicles were impalpable even in the testicle channel.
In premature newborns, the incidence of potential hernia is significantly higher than in mature newborns.
If during the first year of life the testicles didn’t descent into the scrotum, the congenital hernia is developed in 30% of immature male newborns, and potential hernia is registered in 60% of newborns.
MURADOVA S.R.
CORRELATION-STATISTICAL PARAMETERS OF SECRETORY CARDIOMYOCYTES DURING THE USE OF PROPRANALOL IN THE DYNAMICS OF THE EXPERIMENTAL MYOCARDIAL HEART ATTACK
Department of Inner Diseases ¹2, AMU, Baku, Azerbaijan
ABSTRACT. We have carried out a research of the correlation-statistical parameters of paraendocrine secretion in the auricles of 25 dogs (10 of them constituted a control group), using propranolol in the dynamics of the modeled myocardial heart attack.
MURADOVA S.R.
HISTOCHEMICAL AND ELECTRON MIÑROSCOPY PARAMETERS OF SECRETORY CARDIOMYOCYTES DURING THE USE OF ATENOLOL IN THE DYNAMICS OF THE EXPERIMENTAL MYOCARDIAL HEART ATTACK
Department of Inner Diseases ¹2, AMU, Baku, Azerbaijan
SUMMARY
Atrial Natriuretic Factor – ANF – participates in the regulation of the interaction of complicated and regulated organism systems: renin–angiotenzin-aldosterone, simpatoadrenal-kallikrein-kinin. In this connection a further inquiry of their structuro-functional interrelations have a certainly theoretical and practical interest.
I.MUSHKUDIANI, M.BOLKVADZE, G.MURTSKHVALADZE, T.SULAVA
RENAL MORPHO-FUNCTIONAL CHANGES IN ADULT AND NEWBORN DONORS’ KIDNEYS DURING EXTRACORPOREAL CONNECTION IN THE EXPERIMENT
ABSTRACT. Renal morpho-functional changes of adult and newborn donors after 3, 5 hours of extracorporeal grafting of healthy donors to unhealthy recipients have been studied.
Numerous morpho-functional observations have revealed the identity of changes which occurred in the tissue of grafted kidneys of animals of various ages. That gives us the opportunity to recommend transplantation of a newborn’s kidneys to recipients with renal insufficiency.
MORPHOLOGICAL PECULIARITIES OF THE LUNGS OF NEWBORNS WITH DAMAGED SPINAL CORD
A.Natishvili Institute of Experimental Morfology of Georgian AS,
K.V.Chachava Scientific-Research Institute of Perinatal Medicine, Obstetrics and Gynecology, Georgia
ABSTRACT. The authors give the analysis of a rather large material (123) of traumatic damage of the spinal cord, including the picture of the lungs associated with this damage. The material was studied by means of the histological methods (hematoxilin-eosin and Nissl).
According to the presented data, traumatic lesions of the spinal cord, especially and more often of its cervical segment, lead to the disturbance of lungs expansion, and formation of different pneumopaties, and primary and secondary atelectases, hyaline membranes etc.
These morphological data at the same time have certain clinical importance.
N.I.MUCHAIDZE, L.E.GOGIASHVILI, G.S.DANELIA
MORPHOLOGICAL CHANGES IN PREMATURE INFANTS WITH SPINAL CORD INJURY
A.Natishvili Institute of Experimental Morphology of Georgian AS,
K.V.Chachava Scientific-Research Institute of Perinatal Medicine, Obstetrics, and Gynecology Tbilisi
ABSTRACT. The spinal cord of premature infants with intracranial birth injury was investigated. Alterations in the spinal cord were observed in 50% of newborns, predominantly in infants with a history of asphyxia during delivery, and repeated attacks of asphyxia in the early postnatal period. Histological investigations revealed dàmages to moto-and interneurons, including damage to the nervous cells of the phrenic nerve nucleus in some cases. The altered cells were localized in the zones of the collateral circulation at the junction of basins of different spinal cord arterial systems.
G.A.ORAKHELASHVILI, G.G.BARATASHVILI, T.V.SANIKIDZE, R.G.KARCHKHADZE
CHANGES OF PARAMAGNETIC CENTRES AND BIOCHEMICAL INDICES OF BLOOD IN THE PROCESS OF MODELLING AND TREATMENT OF THE EXTREMELY SEVERE CRUSH SYNDROME
Tbilisi State Medical University, Georgia
ABSTRACT. An extremely severe crush syndrome was modeled on 20 rabbits as a result of 6-hour mechanical compression of soft tissues of the left hip by a specially designed apparatus. To make the pathological process even heavier, additionally was bandaged the right hip artery.
Based on the data obtained by the method of electro-paramagnetic resonance and biochemical indexes of blood, it was observed the extremely severe condition of the animals resulting from a strong neuroreflective effect, intoxication and plasma loss. It was followed by a rapid development of the pathological process and death of the animals in the shortest post-compression period (in average 1 hour 50 minutes after decompression).
The treatment was delivered in 1 hour after decompression, when the extremely heavy state of the animals and secondary polyorganic insufficiency were observed. For the treatment were used physiological self solution of 0.9% NaCl and rheoplyglucine (3:1), and antistress preparations with wide range of antistress effect (sodium oxybutyrate, dexazone and 40% glucose).
As a result, lives of the animals were prolonged fourfold. The obtained results suggest that it is essential to begin the genetically justified treatment immediately after rescuing the injured from under ruins with their subsequent evacuation to the field surgical hospital, and further to the stationary hospital for special treatment that can include surgery.
Moscow Medical Academy, Moscow
ABSTRACT. Among the lymphoid formations of the organism, immune structures locating in the walls of hollow internal organs have a special importance. Lymphoid tissue, irrespective of the stage of its morphological maturity, carries out immune supervision in the walls of the hollow internal organs. In spite of the secretory process being realized by the minor intramural glands, alien antigens are seldom washed out with gland secret. Therefore, the excretory ducts of the glands may serve as an original anatomic base for penetrating the antigen material. In the scientific literature, there are found some data about (concerning) the reciprocal location of the glandular and immune structures. However, there was a lack of detailed information on these anatomic formations in the walls of the extrahepatic biliary tract. In our investigation, carried out by means of the macro-microscopic and histological methods used complexively, were shown lymphoid structures in the extrahepatic tract have some affinity with the glandular epithelium. Cells of the lymphoid line, among which prevail small and middle lymphocytes, are always determined near the glands excretory ducts. They are especially multiple near the terminal department of the common excretory duct. The lymphoid elements play the role of original “sentry posts”. Typical lymphoid nodules are rare beside the excretory ducts. That’s connected with a relatively weak gall antigen activity.
Besides, the lymphoid cells are permanently determined in the stroma of the glands locating in the wall of the extrahepatic biliary tracts. Small lymphocytes, plasmatic and other cells form close accumulations in the connective tissue stroma of a gland, especially at mature and elderly ages. Plasmatic cells are determined in the epithelium membrane of the first nets, locating between secretory cells. Probably, such microtopography indicates participation of these cells in the synthesis of the secretory forms of immunoglobulin A. On the whole, the adduced data keeps within (goes in, into) the conception of topographic closeness of glands and immune structures in the walls of the hollow organs.
INDIVIDUAL ANATOMIC VARIABILITY OF THE GLANDS OF HUMAN EXTRAHEPATIC BILIARY TRACT
ABSTRACT. We carried out a complexive morphological study of the minor (intramural) glands of human extrahepatic biliary tract in the postnatal ontogenesis.
By the macromicroscopic method in combination with 0,05% solution of methylene blue in running water we investigated multicellular glands of the bladder ducts, gall-bladder, right, left, common hepatic ducts, and common gall ducts. Previously, all the ducts were dissected along their anterior wall. After fixation of the material in the concentrated ammonium salt of molybdenum acid solution, the material was investigated via a stereomicroscop MBS-9 (magnification 8.16). The preparations were taken from corpses (92 incidents) of deceased people (age: infancy-99) without any anomalies of the biliary tract and pathological changes in the liver, pancreas, and digestive tract.
The analysis of total preparations of the gall-bladder and extrahepatic biliary tract revealed intramural (minor) glands in their 100 %. In the walls of the gall-bladder, for the whole postnatal ontogenesis there can be determined: location of the glands as small groups (by 3-4), paired location of the glands, and also the presence of small and broken lines (chains). In the region of collum of the gall-bladder (sphincter region) we were permanently determining gland accumulations - original “glandular muffs”: by 10-15 glands in the new-born children; by 20-25 glands in the persons at the first mature age, and by 15-20 glands - at the elderly age.
The extrahepatic biliary tract glands have different forms even for the space of the same field of vision (magnification 16). There are distinguished glands of the ovoid, rounded, irregular, filet, polygonal, and other forms. The variety of the glands’ outward appearance, their individual variability correspondes to the common principles of the construction of internal organs glandular apparatus formulated by M.R.Sapin, D.B.Nikityuk.
V.B.SHADLINSKY, S.M.RUSTAMOVA
EMOTIONAL STRESS IS THE PROBLEM IN ENDOCRINOLOGY AND SOCIAL SURROUDING
Department of Human Anatomy, Azerbaijan Medical University, Baku
ABSTRACT. In this research we carried out an interrogatory among the population of Azerbaijan with different diseases of the thyroid gland for 1998, 2000. In 1998 endemic goiter was (constituted) 47.5 %, diffuse-toxic goiter - 25 %. The main part of the patients consisted of the people of the early mature age (22-35) – 16.25 %, and of the second mature age (36-55) – 77.50 %.
Among the exiles (148 persons) were often found patients with different forms of the goiter at mature age, the aggravated disease was rarer in the first (52 %) and second (52 %) stages.
Among the factors causing the diseases stress took 93.2 %, hereditary diseases were on the second place.
The work has been accomplished on the basis of the study of the preparations of the female urethra taken from 182 corpses of women (age: infancy-101 years). It has been established that the glands of the female urethra are unevenly distributed along its perimeter. The thickness of their distribution (7-10 glands per 0.25 cm) is maximal in the posterior wall of the urethra and is minimal in its anterior wall, occupying the interstitial position in the lateral walls of the organ.
E.SHVELASHVILI, N.MERABISHVILI
THE INFLUENCE OF IRON AND COPPER QUANTITATIVE INDICES ON PLACENTAL TISSUE
RESPIRATION PROCESSES
Tbilisi State Medical University, Georgia
ABSTRACT. The aim of this study is to quantify the essential trace elements - iron and copper - in the placenta during term and preterm delivery. The content of iron and copper was determined in ash, using the method of emission spectral analysis.
The present results show that the mean concentrations of iron and copper in preterm parturients are significantly lower when compared with term parturients. It is supposed, that low iron (Fe) and copper (Cu) level in the placenta during preterm delivery causes the reduction of tissue respiration processes intensity.
In the respiratory chain, iron deficiency causes a decrease in electron transport, which conduces reduction of cytochromic system function. The decreased copper quantitative index reduces cytochromoxidaze activity, because copper atoms realize transport of electrons on the oxygen in the respiratory chain. The decreased content of this active components of the cytochromic system reduces ATP synthesis, which cause retardation of vital processes. It is supposed that the disturbance of mitochondrial respiration and oxidative phosphorylation processes cause tissular hypoxic-ischemic damage and consequently, placental insufficiency.
JSC “Travmatology”, Tbilisi, Georgia
ABSTRACT. Selection of methods of treatment while the gunshot fractures of long bones are considered to be active question in modern urgental traumatology.
There are analyses of treatment of 300 patients of gunshot fractures. The patients have treated at Tbilisi in clinic “Traumatology” and at Yemen central military hospital in Sannaa.
By us considered to be the most rational method - external multi plane fixation of bone fragments with rod - apparatus.
G.CHAPIDZE, A.CHUKHRUKIDZE, A.ALADASHVILI, D.IOSELIANI, S.APANADZE
BALLOON ANGIOPLASTY AND STENTING OF CORONARY ARTERIES WITH STABLE ANGINA
,,Emergency Cardiology Center”, Tbilisi, Georgia
ABSTRACT. From 1998 to 2003 at the ,,Emergency Cardiology Center” 150 patients with stabile angina underwent transluminal balloon angioplasty and coronary artery stenting, 138 male, 12 female, average age 55,8±8,6 yaer. During polyprojectional selective coronarography haemodynamically meaningful stenosed lesions were evaluated in 184 vessels, mainly in the following cases: left anterior descending artery - 44%, right coronary artery - 27,2%, circumflex artery - 12,5%, marginal branch 10,9%. According to ACC/AHA the type of classifications as follows: A - 10 (5,4%), B1 - 75 (40,8%), B2 - 24 (13%), C - 24 (13%). Dilatation had be performed: for one vessel 119 patients, for two vessels – in 29 patients, for three vessels - is 2 patients. Stenting had be performed in 89,7% of the cases. On 123 patients complete release of angina and 27 patients showed marked improvement with significant growth of physical loading tolerance. Consequent 6 months after revascularization development of myocardial infarct was observed in 1 patient, recurrent angina in 23 (15,3%) patients. Need of repeat revascularization of miocard occurred in 7 patents including the case of balloon angioplasty in 4 patients and coronary bypass surgery in 3 patients.
G.CHAPIDZE, S.KAPANADZE, D.SAMADASHVILI, N.DOLIDZE, L.CHAPIDZE, M.NEMSADZE, E.SHENGELIA
SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION AND ITS CORRECTION IN SECONDARY
ÑORONARY PREVENTION
Emergency Cardiology Center, Tbilisi, Georgia
ABSTRACT. Endothelial dysfunction (ED) is an independent predictor of cardiovascular events, providing valuable prognostic information. Coronary risk factors are associated with ED and their coexistence is associated with nitric oxide (NO) metabolism end product- NO3 as an indirect estimation of ED. The work was carried out in the department of Secondary Prevention of CHD, therefore 74 patients with coronary artery atherosclerosis were investigated. Most of the patients had undergone myocardial revascularization procedures - CABG and PCI. 4 types of NO levels were observed: extreme deficite- <5 mcmol/L (n=15), low plasma levels- 5-14 mcmol/L (n=200), normal levels- 15-24 mcmol/L and increased levels- >24mcmol/ L (n=19). Multivessel disease was associated with extremely low or excessive levels of NO. It is noteworthy that from three patients with recurrent angina undergoing CABG and PCI two had extreme deficite of plasma NO concentrations and one-increased concentrations. Both abnormalities indicated severe coronary atherosclerotic process wich was connected with recurrent incidents of angina. Patients with 0-1 risk factor mainly had normal plasma concentrations of NO and with 2 + risk factors-its abnormal levels. We found close relationship between ED assessed by plasma NO concentration and coronary risk factors such as dyslipidemia , especially elevated levels of LDL-C, hypertriglyceridemia and lowered levels of HDL-C as well as hypertension, diabetes, excessive weight and inadequate physical activity. Normal plasma NO concentrations mostly occurred in patients treated with statins and ACE inhibitors. Hyperaggregability of platelets was not observed in patients with normal NO levels. Increased levels of fibrinogen was mainly found in patients with abnormal plasma concentrations of NO.
In conclusion, obtained data of our trial suggest that plasma nitric oxide examination has a diagnostic and prognostic value to identify patients at risk and to control the efficacy of pharmacologic interventions in clinical practice. It may be one of the primary targets in the effort to optimize individualized therapeutic strategies, particularly in preventive cardiology.
G.CHAPIDZE, L.RIGVAVA, S.KAPANADZE, I.CHIKOBAVA
PECULIARITY OF THE ACUTE MYOCARDIAL INFARCTION IN WOMEN
Emergency Cardiology Centre, Tbilisi, Georgia
ABSTRACT. The aim of our investigation was to study peculiarity of the acute myocardial infarction in women. 35 women with acute myocardial infarction were investigated (average age 63).
Lethality in women with myocardial infarction was high (17,1%) in spite of the early hospitalization (within 5 hours 80% of patients) and high frequency of thrombolytic therapy (65%).
In complications prevalenced cardiac insufficiency.
M.V.TSILOSANI, O.V.TSINTSADZE, T.A.DJORBENADZE
FOR THE PROBLEM OF THE BENIGN PROSTATE HYPERPLASIA AND INTRAEPITHELIAL NEOPLASIA FREQUENCY IN THE GERONTOLOGICAL ASPECT
Georgia State Medical Academy, Chair of Clinical Pathology,
Al.Culukidze National Centre of Urology, Tbilisi
ABSTRACT. Benign Prostatic Hyperplasia (BPH) is characterized by definite complex of symptoms, representing one of the most frequent diseases among men. Intraepithelial neoplasia (PIN) differs from BPH and is not manifested clinically.
The aim of our research was to determine BPH frequency and screening PSA level in the gerontological aspect on the basis of the morphological study of the biopsy material (462 cases), which has been made for five years (1998-2002).
Our research showed that in the most cases (79.7%) BPH was accompanied by Intraepithelial Neoplasia and it occurred most frequently in aged patients (49.37%).
Department of medicine, Tbilisi Iv.Javakhishvili State University
ABSTRACT. The sinusoid cells are playing major role in inter-hepatic homeostasis. To understand the role of sinusoid cells in pathogenesis, we need to know their normal date. The morphological and functional analysis of Kupffer’s cells, endotheliocytes, lipocytes and Pit-cells in norm has been held. The comparative morphometrical spot account method (Weibel, 1963) was used in this study; sinusoid cells make up 34,5% of total amount in liver. Percentage of separate sinusoid cells in microcirculatory vessels was counted by the same method. It was found that endotheliocytes make up 64,5% of total amount; Kupffer’s cells –21,5%; lipocytes –12%; and Pit-cells 3%. Ultrastructural changes of nucleolus and nature of Ag-Nor-proteins distribution in sinusoidal cells have been studied: most of sinusoid cells of normal white rats from adult group have one or two Ag-positive zones. Most of these zones are spherical shape. Single Ag-positive zones are similar to the ring-shaped nucleoli. This shows that adult white rats liver sinusoid cells are not active at norm.
D.KHERODINASHVILI, M.ARDJEVANISHVILI, M.RIJVADZE, N.MAISURADZE, N.DATOSHVILI
ABSTRACT. Electroexision of the utero cervix has been done in 82 patient with ectopia, condilomas, in 78,3% the operation has been done on the base of immunostimulating, antiviràl and laser Therapy.
The duration of the disease ranged from 1 to 10 years. Before the operation cervicoscopia and cytological analyze of the vaginal smear has been done.
The results of the study has revealed, that electoexcision of the ufue cervix on the base of immunostimulating, antiviral, antibacterial and laser Therapy is the effective method for the treatment lessions.
The characteristic complications like cervical tissues traumas and consecutive stenosis have not been documented using the a bone mentioned combination method.
N.KHODELI, D.PARTSAKHASHVILI, E.INAURI, M.GOGATISHVILI, N.MDIVANI
SPECIAL TOPOGRAPHIC CHARACTERISTICS OF CONNECTING SPACES OF HUMAN SKULL
Medical Faculty of Iv.Javakhishvili State University, Department of Normal and Clinical Human Anatomy, Tbilisi, Georgia
ABSTRACT. The special literature describes the soft tissues of human head differently. For this reason, the topography of connective tissue spaces of this area calls for detailed reexamination. The results of preparing 5 corpses reveal that according to the peculiarities of skull bone composition, 8 connective spaces can be defined in epicranial area. In contrast with the other authors, the work delineates additional spaces: (subpericranialis frontalis,occipitalis et parietalis).
During preparation of soft tissues around the temple, 5 connective tissue spaces were separated. Within the bones of temple area we discovered 3 additional, isolated spaces (more specifically squama temporalis, alla major ossis sphenoidalis et facies temporalis ossis frontalis). The existence of total of 16 such connective tissue spaces were recorded in the epicranial end temporal area.
N.KHODELI, T.EKVTIMISHVILI, D.PARTSAKHASHVILI, T.SOLOGASHVILI
THE DEVELOPMENT OF ATRAUMATIC METHODS OF BLOOD TRANSFUSION IN THE ARTIFICIAL BLOOD CIRCULATION SYSTEM
Medical Faculty of Iv.Javakhishvili State University, Department of Normal and Clinical Human Anatomy, Tbilisi, Georgia
ABSTRACT. The traumatic effects of roller pumps on the blood cells and on the entire homeostasis in a system of artificial circulation are well documented. On 17 experiments on animals, we tested a relatively atraumatic and highly physiological method of blood transfusion in a perfusion system.
The method was based on moving the blood volume through a vacuum into hermetic reservoirs located at various heights. The effectiveness of the system consisted of: blood flow generation 2 liters/min. and blood transfusion height of 1.5 meters. The size of the vacuum varied from –5 to –10 mmHg.
JAFAROV C.M., MAMEDOV R.A., GASIMOV E.M., JAFAROV E.C., ABBASOV P A.
PROGNOSTIC VALUE OF HISTOMORPHOLOGY RESEARCHES OF THE MUCOUS MEMBRANE OF THE STOMACH AT PATIENTS WITH FAVORABLE CURRENT AND IT IS LONG NOT CICATRIZING ULCER
General surgery department, AMU, Baku, Azerbaijan
ABSTRACT. Valuable though and in a smaller measure for occurrence of the complicated current of a stomach ulcer is the arrangement of a gastritis in a periulcerous zone.